Study of Clinico Pathological Correlation in Autoimmune Bullous Disorders

Background: Immune mediated vesiculobullous diseases can be diagnosed by close attention to the clinical details, histological confirmation and the clinical setting of the blistering. Confirmatory studies such as immunofluorescence will help in diagnosis of cases where histopathological features alone are not diagnostic. To evaluate clinical findings in association with histopathological findings, to study the histopathological findings in various immunobullous lesions of skin, and to confirm with immunofluorescence wherever possible Aim: The aim is to study histopathology of various Autoimmune vesicobullous disorders and its correlation with clinical evaluation in patients attending DVL department, Guntur medical college. Material & Methods : A total of 80 patients of various bullous disorders attending to department of DVL in one and half year period from July 2015 to december 2016 were analysed. of these females (44), males (33), and (3) were children .The clinical features and histopathology were correlated for the diagnosis and direct immunofluorescence (DIF) was done whenever necessary. Results: out of 80 patients we studied, females were 44( 55 %), males 33(41.25%), children 3 (3.75%). 40 to 50 yrs age group were more commonly affected .we studied & correlated histopathology and DIF with clinical findings , of these 43 patients (53.7%) were pemphigus vulgaris. 18 (22.6 %) were bullous pemphigoid. 4 were (2.51%) Dermatitis herpetifiormis, 2 (2.51 %) were pemphigus vegetans, 5 were pemphigus foliaceous(6.25%) , 3 were CBDC ( 3.72%) . Discussion & Conclusion : Histopathology findings were correlated with clinical diagnosis in majority (95.5%) of autoimmune bullous disorders except few cases (5.25%) where diagnosis is done by immunoflourescence findings. To conclude, the correlation between clinical findings, Histopathology and Immunofluroscence plays a predominant role to confirm the atypical appearance of autoimmune blistering diseases.